by Chhavi Madaan | 2020-08-13

While the enormity of the COVID-19 virus seems to be evolving drastically, UCSF researchers claim ‘AeroNabs’ Nasal Spray could halt the spread of the COVID-19 virus.

The research was led by Michael Schoof, a graduate of the University of California, San Francisco. Through extensive experimentation, the team has developed synthetic molecules that prove to be highly effective against the COVID-19 virus. A brief study of how the Coronavirus thrives in our system is essential to deciphering the molecules’ impact in curbing it.

A Lock and Key Interaction

Coronavirus uses Spike Proteins to infect the cells in our lungs and the air tract. Spikes are what give the virus a crown-like appearance under microscopic observation. The spikes interact with the receptors on human cells, much like a lock-and-key interface, and then manipulate the cells themselves to simulate coronavirus production.

A search for nanobodies that could impede the virus-cell receptors is what steered the research.

Development of Nanobodies as a Defender against Coronavirus

Through experimentation, scientists found certain nanobodies could adhere to the virus, eventually hampering the virus-cell interaction.

Nanobodies are smaller in size to antibodies and are more stable. This discovery upgrades the scope of experimentation while preserving the efficacy of the by-product.

Three nanobodies were fused to form a single molecular chain which derived 20,000 times greater potency than a single nanobody.

The final stage included conducting several tests to prove the stability and consistency of the nanobodies. ‘AeroNabs’ Nasal Spray is the aerosolized form of these integrated nanobodies.

Peter Walter, the co-inventor of AeroNabs, compares it to a PPE kit stating it to be a “molecular form of PPE.” The news of the discovery evokes a sense of hope until the arrival of a vaccine.

Manufacturing AeroNabs

Scientists aim to make the product available at as low a cost as possible. However, the AeroNabs Nasal Spray is yet to be tested on humans. The experiments conducted on lab specimens have yielded definite conclusions. Meanwhile, the Scientists urge all to be patient since mass-producing of the nasal spray requires ample time.

The invention of AeroNabs Nasal Spray can be reckoned as a breakthrough in the attempts to discover the Coronavirus vaccine. It is predicted as a significant benefactor in breaking the expansion of the COVID-19 virus worldwide.

Currently, UCSF researchers are also communicating with retail allies who would “manufacture and distribute” AeroNabs Nasal Sprays and Inhalers shortly.

Stay Safe. Stay Healthy. Stay Tuned.

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